Safety assessment of hydroxypropyl methylcellulose as a ...

Hydroxypropyl methyl cellulose (HPMC; CAS No. -65-3) is an odorless and tasteless, white to slightly off-white, fibrous or granular, free-flowing powder that is a synthetic modification of the natural polymer, cellulose. It is used in the food industry as a multipurpose food ingredient. HPMC is approved by FDA as both a direct and an indirect food additive, and is approved for use as a food additive by the EU. The JECFA has evaluated the food uses of HPMC and established an acceptable daily intake (ADI) of 'not specified' for such uses. Based on the no-observed-adverse-effect level (NOAEL) of mg/kg body weight/day from a 90-day feeding study in rats, a tolerable intake for ingestion of HPMC by humans of 5 mg/kg body weight/day is posited and, as such, is more than 100-fold greater than the estimated current consumption of 0.047 mg/kg body weight/day.

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Attention: HPMC and Sepimax Zen can both thicken 70% isopropyl alcohol at 3%. 

CAS No. -65-3

Hydroxypropyl Methylcellulose (HPMC) is multifunctional as a lubricant, foam enhancer and stabilizer, thickener, emulsion stabilizer and film former for hair and skin care products. HPMC is especially useful in surfactant systems for its foam enhancing properties, helping with the formation of bubble structure, leading to richer, longer lasting lather. HPMC has a high tolerance for both salt and alcohol.

Techniques for Dispersion
 

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• The preferred method is to begin by heating approximately 1/3 of the total formulation water to 167°F (75°C) or higher. Add the HPMC to the vortex of agitated and heated water. Mix until fully dispersed. HMPC will not dissolve at this temperature. After complete dispersion, add the remaining water at room temperature or colder and continue mixing for 30 minutes after the total solution has cooled to 77°F. (25°C) or less. Proceed with the formulation.
   
• If heating is impossible, it is preferred to slurry the HPMC in a non-solvating media, such as glycerin or PEG, then add the slurry to the vortex of vigorously agitated water. Adding HPMC directly to cold water is not preferred, but if necessary, must be done very slowly under vigorous agitation. Expect longer mixing times for complete dissolution.

INCI: Hydroxypropyl Methylcellulose

California Prop 65 Statement: The following statement is made in order to comply with the California Safe Drinking Water and Toxic Enforcement Act of . This product is not known to the State of California to cause cancer, birth defects or other reproductive harm.

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